CONTRIBUTION OF COMPONENTS FOR ONE TABLET: dry extractofMilk Thistle (Silybum marianum) fruits, titrated at 80% by silymarin 200 mg (contribution in silymarin 160 mg). Extractofred rice fermented with Monascus purpureus titrated at 1.5% in monacolin 200 mg (contribution in monacolin 3 mg). Coenzyme Q10 titrated at 10% 100 mg (contribution in Coenzyme Q10, 10 mg). Microcrystalline cellulose, arabic gum. Aplanospores microalgae Haematococcus pluvialis titrated at 2.5% in astaxanthin 40 mg (contribution in astaxanthin 1 mg). Calcium phosphate. Antiagglomerants: vegetable magnesium stearate, silicon bioxide. Resveratrol titrated at 98% 10 mg (contribution in resveratrol 9.8 mg). Folic Acid 200 mcg. Contains soy derivatives.
Product included in the Register of the Italian Health Ministry, Code M 10 45921-Y
Product included in the Register of the Belgian Health Ministry, Code NUT/PL 1653/34
COLERIL Plus is a supplement containing herbal ingredients, Coenzyme Q10, Resveratrol and Folic acid, that facilitate the control of plasma cholesterol in addition to a diet generally adequate for this purpose.
SUGGESTIONS OF USE: one tablet daily, before bedtime.
WARNINGS: Keep out of reach of children under three years. Do not exceed the recommended daily dose. The product should be used in a varied and balanced diet and a healthy lifestyle.
NOTES: MONASCUS PURPUREUS has, among its active ingredients, an inhibitor of HMG-CoA reductase, enzyme that is responsible for checking the rate of cholesterol synthesis. It contains monacolins of which the most abundant is Monacolin K, also named Lovastatin, that inhibits the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase): 21st step to cholesterol synthesis (Endo 1976). Without this enzyme, the entire sequence of cholesterol synthesis goes to be blocked; that’s why it constitutes an elective target for controlling cholesterol levels in the blood. MILK THISTLE (Silybum marianum) contains Silymarin and has hepatotropic activity. Silimarin has a strong hepato-protective action against toxic substances; indeed, laboratory tests and clinical trials showed that it has effects on hepatocyte cell membrane, preventing or makin’ very difficult the penetration of various toxic substances in the liver (membranotropeactivity), thus far to block fat degeneration and cell necrosis. COENZYME Q10 is useful because HMG-CoA reductase, which takes part in the cholesterol synthesis, takes also part in the Coenzyme Q10 synthesis; that’s why if you are submitted to cares reducing your cholesterolemy (statines conteined in Monascus p.), you can have a coenzyme values reduction. Natural Astaxanthin, a carotenoide, is extracted from HAEMATOCOCCUS PLUVIALIS alga. Several kinds of Astaxanthin are put on the markets: chemically one obtained by yeast and natural one obtained by Haematococcus Pluvialis, a microalga growing at the Hawaii islands. Natural Astaxanthin doesn’t show toxicity levels because it’s a totally natural substance and a large number of studies have confirmed its absolute alimentary security. Astaxanthin has a big antioxidative power and it’s much more effective than beta-carotene and vitamin E. World Health Organization points out RESVERATROL to be a substance able to reduce of 40% cardiovascular risks. As antioxidant it protects towards an ampler range of free radicals in comparison to the Vitamin E. Resveratrol promotes the production of nitrogen oxide, biochemical mediator produced in living organisms in order to control many of their functions; nitrogen oxide relaxes and dilates arteries. Resveratrol inhibits platelets aggregation, preventing the thrombin action; it prevents low-density-lipo-protein oxidation (LDL-Cholesterol). Nowadays, there’s not much Resveratrol in wine; indeed, there’s not nearly more trace and this because of making use of pesticides. That’s why for being able to assume it we have to produce extracts containing adequate amounts of it. FOLIC ACID is able to reduce homocisteine, intermediate product created from the conversion of methionine amino acid to cisteine and standing in blood flow, of which high levels bring on some pathologies (cardiovascular risks, atherosclerosis, osteoporosis). Folic acid deficiency can affect the cholesterol level because it is essentially required to use fats
- Tina Cecchini - "Enciclopedia delle erbe medicinali, …………" - DE VECCHI EDITORE
- Alberto Fidi - "Erbe e Piante medicinali" FRATELLI MELITA EDITORI
- Benigni R., Capra C., Cattorini P.E. - "Piante medicinali: chimica, farmacologia e terapia" Inverni della beffa ed, Milano.
- Duraffourd C., D’Ervicourt L., Lapraz J.C. - "Cahieres de Phytotérapie clinique" Masson ed., Paris 1983
- Maugini E. - "Botanica farmaceutica" CLUSF ed., Firenze 1976
- Pomini L. - "Erboristeria italiana" - Vitalità ed
- Valnet J., Duraffourd C., Lapraz J.C. - "Phytotérapie et aromatherapie" - Presse de la Renaissance, Paris 1978
- Penso G. - "Piante medicinali nella terapia medica" - Org. Med. Farm. Ed., Milano
- Enrica Campanili - "Dizionario di fitoterapia e piante medicinali" - Tecniche Nuove - MI
- Larousse - “Encyclopédie des PLANTES MÉDICINALES identification, préparations, soins” - Larousse-Bordas - 1997
- Tom Wilsons - “Guarire con le erbe, i consigli, le malattie, le ricette, le dosi nella più ricca raccolta di erboristeria” - Fratelli Melita Editori
- Nishino, H. (1998) Cancer prevention by carotenoids. Mutat. Res., 402:159-163.
- Ames, B. N., Shigenaga, M. K., and Hagen, T. M. (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA., 90(17):7915-7922.
- Terao, J. (1989) Antioxidant activity of beta-carotene-related carotenoids in solution. Lipids, 24: 659-661.
- Coyle, J. T. and Puttfarcken, P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science, 262:689-695.
- Jyonouchi H., Sun S., Mizokami M., and Gross M. D. (1996) Effects of various carotenoids on cloned, effector-stage T-helper cell activity. Nutr. Cancer, 26(3):313-324.
- Conn , P. F., Schalch, W., and Truscott, T. G. (1991) The singlet oxygen and carotenoid interaction. J. Photochem. Photobiol. B, 11:41-47.
- Kobayashi, M., Kakizono, T., Hishio, N., Nagai, S., Kurimura, Y., and Tsuji, Y. (1997) Antioxidant role of astaxanthin in the green alga Haematococcus pluvialis. Appl. Microbiol. Biotechnol., 48:351-356.